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Chronic spontaneous urticaria: Understanding the persistent burden of hives

Conference Insider Editorial · September 30, 2026

Duration, history, and symptom burden provide a useful starting point when evaluating recurrent hives.

An allergist discussing a skin concern with an adult patient

When hives become chronic

Urticaria consists of raised, itchy welts that may be red or skin-colored. Symptoms persisting beyond six weeks warrant consideration of chronic urticaria. In chronic spontaneous urticaria, a clear external trigger often cannot be identified, which can make the condition frustrating for patients.

History guides the evaluation

ACAAI emphasizes the importance of reviewing medical history, exposures, and medications. A record of symptoms over time can support the discussion. Patients may assume that a food allergy explains recurring hives, but foods are not the trigger for most people with chronic spontaneous urticaria.

A continuing care conversation

Antihistamines are a mainstay of management, and ongoing symptoms may require specialist assessment of additional options. The practical goal of follow-up is to understand symptom control and its effect on daily life. Treatment choices should reflect the individual clinical assessment and current guidance rather than a generalized approach to every case of hives.

Source: ACAAI — Chronic spontaneous/idiopathic urticaria.